Transgender persons (about 0.6 percent or more of the U.S. population) have a strong inner sense that their bodies and the gender assigned to them at birth are not aligned with their gender identity. They may be assigned-at-birth males who identify as female (male to female or MTF) or assigned-at-birth females who identify as male (female to male or FTM).
As a transgender care therapist I seek to understand how my transgender and gender-non conforming clients identify, especially given that gender identity is now considered to be more a spectrum between male and female. Some gender-nonbinary persons do not seek hormone or surgical treatment and are comfortable with a more nonbinary gender expression, whereas others do seek medical interventions.
However with some exceptions, transgender persons desire and, if at all possible, pursue hormone and surgical treatment to experience alignment between their bodies and minds. In other words, most transgender persons desire and pursue transition to the gender with which they identify.
Clients, family members and the general public often want to know how this happens or why some people are transgender. The etiology of transgender may be understood as a complex interaction of social/cultural, cognitive and primarily biological factors, consistent with explanations of gender identity in general.